Next week will see the beginning of a new era for The Tonight Show, as Jimmy Fallon begins his reign as host, thus marking the end of Jay Leno’s 22 year run.

It’s set to be an enthralling week, with a run of guests such as Michelle Obama, Lady Gaga and Justin Timberlake in Fallon’s first five days. Take a look at the breakdown of Fallon’s first week on The Tonight Show, one that includes U2 as his premier musical guest:

The Tonight Show with Jimmy Fallon, first week lineup:

Feb 17: Will Smith, musical guest U2
Feb 18: Jerry Seinfeld, Kristen Wiig, musical guest Lady Gaga
Feb 19: Bradley Cooper, musical guest Tim McGraw
Feb 20: Michelle Obama, Will Ferrell, musical guest Arcade Fire
Feb 21: Justin Timberlake

Following the host to his new show will be The Roots, maintaining their roll as Fallon’s house band. Former Fallon SNL castmate Seth Meyers will be taking over as the new Late Night host, with fellow SNL alum Fred Armisen assuming the role as bandleader on the program.

As a goodbye to the show he’s hosted since its beginning, in 2009, Fallon sang along with The Muppets to The Band’s “The Weight.” Hold back the tears and watch below: